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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 12 Reviews
8.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
7
Curcumin's potential in prostate cancer
The Association Between Anti-Neoplastic Effects of Curcumin and Urogenital Cancers: A Systematic Review.
High relevance to prostate cancer
We evaluated the anti-cancer effects of turmeric, specifically focusing on how it influences prostate cancer. Our systematic review examined various studies that investigated the relationship between curcumin, a component of turmeric, and the regulation of microRNA expressions linked to prostate cancer.
Among the studies we analyzed, we found that curcumin appears to play a significant role in combating prostate cancer by modulating specific microRNAs. This compound seems to promote tumor suppression by increasing beneficial microRNAs while simultaneously decreasing those associated with cancer progression.
By effectively altering the balance of these molecules, curcumin is thought to inhibit cell proliferation and encourage apoptosis, or programmed cell death, in prostate cancer cells. Overall, the evidence suggests that turmeric may serve as a valuable complementary approach in the fight against prostate cancer.
Among the studies we analyzed, we found that curcumin appears to play a significant role in combating prostate cancer by modulating specific microRNAs. This compound seems to promote tumor suppression by increasing beneficial microRNAs while simultaneously decreasing those associated with cancer progression.
By effectively altering the balance of these molecules, curcumin is thought to inhibit cell proliferation and encourage apoptosis, or programmed cell death, in prostate cancer cells. Overall, the evidence suggests that turmeric may serve as a valuable complementary approach in the fight against prostate cancer.
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8
Curcumin shows promise for prostate cancer
Application and potential value of curcumin in prostate cancer: a meta-analysis based on animal models.
Direct focus on prostate cancer
We examined the effects of curcumin, a compound derived from turmeric, on prostate cancer using various animal studies. By digging through numerous scientific databases, we gathered data from research up to September 2023 to understand better how curcumin might inhibit prostate tumor growth.
Our findings showed that curcumin exhibits promising properties that may help in the treatment of prostate cancer. It appears to slow down tumor growth and has a beneficial effect on the disease, suggesting that there is potential for curcumin to be used in human clinical settings. However, it’s important to note that the studies we included varied significantly in their designs and outcomes, which highlights the need for more controlled trials in humans to fully grasp how effective curcumin could be.
Overall, while the initial evidence is encouraging, we acknowledge that more research is necessary before we can draw definitive conclusions about the benefits of curcumin for prostate cancer in people.
Our findings showed that curcumin exhibits promising properties that may help in the treatment of prostate cancer. It appears to slow down tumor growth and has a beneficial effect on the disease, suggesting that there is potential for curcumin to be used in human clinical settings. However, it’s important to note that the studies we included varied significantly in their designs and outcomes, which highlights the need for more controlled trials in humans to fully grasp how effective curcumin could be.
Overall, while the initial evidence is encouraging, we acknowledge that more research is necessary before we can draw definitive conclusions about the benefits of curcumin for prostate cancer in people.
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8
Curcumin inhibits prostate cancer growth
Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway.
Focus on curcumin's effects
We explored how curcumin, a compound found in turmeric, can impact prostate cancer and its more challenging form, castration-resistant prostate cancer (CRPC). In our investigation, CRPC cells were treated with curcumin, and we used various tests to gauge cell viability and check for apoptosis, which is a form of programmed cell death important in cancer treatment.
Our findings revealed that curcumin treatment led to a decrease in the activity of insulin-like growth factor 1 receptor (IGF-1R), a molecule that often promotes cancer growth. We observed that curcumin also inhibited the PI3K/Akt signaling pathway, which is commonly linked to cancer cell survival and proliferation.
This suggests that curcumin triggers mechanisms that can slow down cancer growth and induce cell death in CRPC cells. The results point toward exciting potential for curcumin as a complementary therapeutic strategy for both prostate cancer and CRPC, making it a noteworthy area for further research and clinical exploration.
Our findings revealed that curcumin treatment led to a decrease in the activity of insulin-like growth factor 1 receptor (IGF-1R), a molecule that often promotes cancer growth. We observed that curcumin also inhibited the PI3K/Akt signaling pathway, which is commonly linked to cancer cell survival and proliferation.
This suggests that curcumin triggers mechanisms that can slow down cancer growth and induce cell death in CRPC cells. The results point toward exciting potential for curcumin as a complementary therapeutic strategy for both prostate cancer and CRPC, making it a noteworthy area for further research and clinical exploration.
Read More
Most Useful Reviews
7
Stronger antioxidant
Curcumin is known for its powerful anti-cancer actions and strong antioxidant properties. I prefer the Drs. Best 1000 mg caplets over the Jarrow formula for affordability and take it twice daily.
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8.3
Joint support
I appreciate the effectiveness of curcumin for reducing inflammation. It is particularly helpful for my joints and cartilage during my cancer therapy.
Read More
9.5
Cancer remission
I have been taking 2 grams (4 capsules) of curcumin daily since my stage 4 breast cancer diagnosis over a year ago. Within three months, I went into remission, and all tumours have disappeared. I have now been in remission for eight months with no evidence of disease.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
9
Turmeric compound enhances cancer therapy
Bisdemethoxycurcumin Augments Docetaxel Efficacy for Treatment of Prostate Cancer.
Supports turmeric in combination therapy
We explored the potential of bisdemethoxycurcumin (BDMC), a prominent compound from turmeric, in enhancing the effectiveness of Docetaxel (DTX), a standard treatment for prostate cancer. By conducting both in vitro and in vivo studies, we assessed how these two treatments work together to combat androgen-independent prostate cancer.
In our experiments, we cultured PC3 and LNCaP cancer cells and treated them with BDMC and DTX on their own or as a combination therapy. We observed that the combined treatment significantly inhibited cell growth and triggered apoptosis, which is the process of programmed cell death. This dual treatment also led to effective cell cycle arrest in the G2/M phase, noted by changes in specific protein expressions that regulate these processes.
Interestingly, our in vivo tests using a mouse model demonstrated that the combination of BDMC and DTX showed superior anticancer benefits than DTX alone. This finding suggests that BDMC has great potential as a complementary therapy, enhancing the effects of traditional prostate cancer treatments.
Overall, this research highlights the promising role that turmeric's BDMC could play in the fight against prostate cancer, particularly in improving the efficacy of existing treatments like Docetaxel.
In our experiments, we cultured PC3 and LNCaP cancer cells and treated them with BDMC and DTX on their own or as a combination therapy. We observed that the combined treatment significantly inhibited cell growth and triggered apoptosis, which is the process of programmed cell death. This dual treatment also led to effective cell cycle arrest in the G2/M phase, noted by changes in specific protein expressions that regulate these processes.
Interestingly, our in vivo tests using a mouse model demonstrated that the combination of BDMC and DTX showed superior anticancer benefits than DTX alone. This finding suggests that BDMC has great potential as a complementary therapy, enhancing the effects of traditional prostate cancer treatments.
Overall, this research highlights the promising role that turmeric's BDMC could play in the fight against prostate cancer, particularly in improving the efficacy of existing treatments like Docetaxel.
Read More
9
Curcumin enhances prostate cancer treatment
Curcumin Enhances the Anti-Cancer Efficacy of CDK4/6 Inhibitors in Prostate Cancer.
Study assesses combination effects
We explored the potential benefits of curcumin—a natural compound known for its health-promoting properties—when combined with CDK4/6 inhibitors in fighting prostate cancer, or PCa. The study aimed to see if this combination could enhance the effectiveness of treating this challenging disease.
Using a range of assays, we assessed how well prostate cancer cells responded to the treatment. Notably, the results showed a synergistic effect, where cells treated with both curcumin and the CDK4/6 inhibitor, LY2835219, experienced significantly reduced growth and invasion capabilities. This means that together, these treatments worked better than either one alone.
We also observed changes at the genetic level, with increases in key cell cycle proteins involved in growth regulation. These findings indicate that using curcumin alongside CDK4/6 inhibitors could be a promising approach, making this combination a potentially valuable strategy in the fight against prostate cancer.
Using a range of assays, we assessed how well prostate cancer cells responded to the treatment. Notably, the results showed a synergistic effect, where cells treated with both curcumin and the CDK4/6 inhibitor, LY2835219, experienced significantly reduced growth and invasion capabilities. This means that together, these treatments worked better than either one alone.
We also observed changes at the genetic level, with increases in key cell cycle proteins involved in growth regulation. These findings indicate that using curcumin alongside CDK4/6 inhibitors could be a promising approach, making this combination a potentially valuable strategy in the fight against prostate cancer.
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8
Curcumin delivery improves prostate cancer treatment
Fluorescent Microorganism-Based Composite: Enhancing Curcumin Delivery Efficiency and its Antitumor Application in Prostate Cancer.
Significant focus on curcumin delivery
We explored the challenges surrounding curcumin, a compound found in turmeric known for its antioxidant and anti-inflammatory properties, particularly in the context of treating prostate cancer. The study aimed to improve its effectiveness by creating a specialized carrier, a microorganism-metal-organic framework, designed to enhance curcumin's solubility and stability.
Our research demonstrated that this new composite carrier, when loaded with curcumin, significantly increased the compound's delivery efficiency. We observed that the enhanced formulation was able to reduce the viability of prostate cancer cells dramatically—by around 50%—at a concentration of 20 µM after 48 hours of treatment.
Moreover, through our analysis of gene expression related to apoptosis, we found that the composite effectively induced cell death in cancer cells—a key goal in cancer therapies. This suggests that curcumin, when properly delivered, can have a powerful antitumor effect, presenting promising potential for future prostate cancer treatments. Ultimately, our findings highlight the importance of improving drug delivery systems for enhancing the therapeutic possibilities of natural compounds like curcumin in prostate cancer care.
Our research demonstrated that this new composite carrier, when loaded with curcumin, significantly increased the compound's delivery efficiency. We observed that the enhanced formulation was able to reduce the viability of prostate cancer cells dramatically—by around 50%—at a concentration of 20 µM after 48 hours of treatment.
Moreover, through our analysis of gene expression related to apoptosis, we found that the composite effectively induced cell death in cancer cells—a key goal in cancer therapies. This suggests that curcumin, when properly delivered, can have a powerful antitumor effect, presenting promising potential for future prostate cancer treatments. Ultimately, our findings highlight the importance of improving drug delivery systems for enhancing the therapeutic possibilities of natural compounds like curcumin in prostate cancer care.
Read More
8
Curcumin inhibits prostate cancer growth
Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway.
Focus on curcumin's effects
We explored how curcumin, a compound found in turmeric, can impact prostate cancer and its more challenging form, castration-resistant prostate cancer (CRPC). In our investigation, CRPC cells were treated with curcumin, and we used various tests to gauge cell viability and check for apoptosis, which is a form of programmed cell death important in cancer treatment.
Our findings revealed that curcumin treatment led to a decrease in the activity of insulin-like growth factor 1 receptor (IGF-1R), a molecule that often promotes cancer growth. We observed that curcumin also inhibited the PI3K/Akt signaling pathway, which is commonly linked to cancer cell survival and proliferation.
This suggests that curcumin triggers mechanisms that can slow down cancer growth and induce cell death in CRPC cells. The results point toward exciting potential for curcumin as a complementary therapeutic strategy for both prostate cancer and CRPC, making it a noteworthy area for further research and clinical exploration.
Our findings revealed that curcumin treatment led to a decrease in the activity of insulin-like growth factor 1 receptor (IGF-1R), a molecule that often promotes cancer growth. We observed that curcumin also inhibited the PI3K/Akt signaling pathway, which is commonly linked to cancer cell survival and proliferation.
This suggests that curcumin triggers mechanisms that can slow down cancer growth and induce cell death in CRPC cells. The results point toward exciting potential for curcumin as a complementary therapeutic strategy for both prostate cancer and CRPC, making it a noteworthy area for further research and clinical exploration.
Read More
8
Curcumin may enhance prostate cancer treatment
Curcumin and Its Potential to Target the Glycolytic Behavior of Lactate-Acclimated Prostate Carcinoma Cells with Docetaxel.
Potential benefit of combined treatment.
We explored how curcumin, a compound found in turmeric, affects prostate carcinoma (PC) cells that adapt to lactic acid, a condition often linked to drug resistance. Our study focused on two types of lactic-acclimated PC cells, comparing them to their non-acclimated counterparts. Notably, the acclimated cells showed increased growth, a greater reliance on a process called glycolysis for energy, and reduced sensitivity to the chemotherapy drug docetaxel.
We delved deeper into the underlying mechanisms at play. It became clear that the acclimated cells activated certain growth-related pathways and increased key enzymes associated with glycolysis. When we reduced levels of a specific enzyme, hexokinase 2 (HK2), the acclimated cells exhibited lower growth and energy production, ultimately leading to cell death.
In a promising twist, we found that using curcumin alongside docetaxel in animal models significantly reduced tumor size while enhancing the activity of apoptosis-related proteins. This was consistent across both traditional and 3D culture methods. Interestingly, our findings imply that curcumin could help target the enhanced glycolysis seen in lactic-acclimated PC cells, possibly improving treatment outcomes for prostate cancer patients.
We delved deeper into the underlying mechanisms at play. It became clear that the acclimated cells activated certain growth-related pathways and increased key enzymes associated with glycolysis. When we reduced levels of a specific enzyme, hexokinase 2 (HK2), the acclimated cells exhibited lower growth and energy production, ultimately leading to cell death.
In a promising twist, we found that using curcumin alongside docetaxel in animal models significantly reduced tumor size while enhancing the activity of apoptosis-related proteins. This was consistent across both traditional and 3D culture methods. Interestingly, our findings imply that curcumin could help target the enhanced glycolysis seen in lactic-acclimated PC cells, possibly improving treatment outcomes for prostate cancer patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.8
9.5
Cancer remission
I have been taking 2 grams (4 capsules) of curcumin daily since my stage 4 breast cancer diagnosis over a year ago. Within three months, I went into remission, and all tumours have disappeared. I have now been in remission for eight months with no evidence of disease.
9.5
Cancer in remission
Since I began taking curcumin four months ago, my immune system has strengthened considerably. I also purchased it for my aunt, who was battling stage 4 lymphoma. After about a month of use, her cancer has entered remission. This supplement feels miraculous.
9.5
Recovery promotion
Curcumin can reduce inflammation, kill cancer cells, and act as an antioxidant, helping tissue recovery. Scientific studies also suggest its potential in treating neurodegenerative and psychiatric disorders.
9
Inflammation reduction
Curcumin is a concentrated extract of turmeric root with potent anti-inflammatory properties. It is effective in various cancers, including prostate cancer, and can lower inflammatory markers. The recommended effective dosage is between 1 and 1.5 grams, and it pairs well with Boswellia for digestive tract issues.
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8.8
Cancer prevention
Regular consumption of curcumin might prevent cancer due to its antioxidant capabilities. I believe its benefits are essential for health.
